She parodied the situation when she appeared on The Larry Sanders Show episode "The New Writer" (1996), playing Sanders' new staff writer, whose jokes are not used because of the chauvinism and bias of the male chief comedy writer, who favors the jokes of his male co-writers.
She appeared in three episodes of Larry Sanders during its final two seasons.
Silverman guest-starred in a second-season episode of the USA cable program Monk as Marci Maven.
She returned in the sixth-season premiere and for the 100th episode of Monk.
She had small parts in the films There's Something About Mary, Say It Isn't So, School of Rock, The Way of the Gun, Overnight Delivery, Screwed, Heartbreakers, Evolution, School for Scoundrels, and Rent, playing a mixture of comic and serious roles.
In 2005, Silverman released a concert film, Sarah Silverman: Jesus Is Magic, based on her one-woman show of the same name.
, about a pair of New York comedians (Silverman and director Sam Seder) going to Los Angeles during pilot season to try to get a part in a television series; the film features numerous young comedians in supporting roles but never received a widespread theatrical release.
Silverman and Seder later made a six-episode television series sequel entitled Pilot Season in which Silverman stars as the same character and Seder again directed.
The video turned out to be a song called "I'm Fucking Matt Damon" in which she and Matt Damon sang a duet about having an affair behind Kimmel's back.Silverman played a therapist in a skit for a bonus DVD of the album Lullabies to Paralyze by the band Queens of the Stone Age.Silverman also appears at the end of the video for American glam metal band Steel Panther's "Death To All But Metal." On Jimmy Kimmel Live!For her work on television, she has won two Primetime Emmy Awards.Silverman was a writer and occasional performer on Saturday Night Live, and starred in and produced The Sarah Silverman Program, which ran from 2007 to 2010 on Comedy Central, for which she was nominated for a Primetime Emmy Award for Outstanding Lead Actress in a Comedy Series.