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However, the data from the ruptured aneurysms also suggest that larger aneurysms are slightly older which indicates that our method is valid because larger aneurysms should take longer to form.

We have assessed the age of collagens I and, V which are the main molecular components of the aneurysm mass.

Michael’s Hospital, Department of Surgery, University of Toronto, Ontario, Canada (N. Although preliminary, our findings may have implications for the biological and structural stability of ruptured and unruptured intracranial aneurysms.

C levels correlated with patient age and aneurysm size in patients with ruptured aneurysms. Michael’s Hospital, Department of Surgery, University of Toronto, Ontario, Canada (N. Collagens were extracted by digestion with 100 μg pepsin/g of tissue at 4°C for 72 hours and were precipitated for 6 hours after addition of solid Na Cl to a final concentration of 2.5 mol/L. H.); Institute for Physiological Chemistry and Pathobiochemistry, Westfalian Wilhelms University, Münster, Germany (R. B.); Center for Accelerator Mass Spectrometry, Livermore, CA (B. Michael’s Hospital, Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Tissue fragments were minced with a scalpel and suspended in at least 1 m L of 20 mmol/L HCl.C levels underlines assumptions on development of ruptured aneurysms.Ruptured aneurysms of older patients seem to contain slightly older collagen, which implicates that if an aneurysm does not rupture at an early stage, it may stabilize, although it may either grow and/or rupture subsequently.

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